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MRPL23 a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. The gene is biallelically expressed, despite its location within a region of imprinted genes on chromosome 11. [provided by RefSeq, Jul 2008]
Protein type: Mitochondrial; RNA-binding; Ribosomal
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: fibrillar center; mitochondrial inner membrane; mitochondrial large ribosomal subunit; mitochondrion
Molecular Function: protein binding; RNA binding; structural constituent of ribosome
Biological Process: mitochondrial translation; translation
Reference #:  Q16540 (UniProtKB)
Alt. Names/Synonyms: 39S ribosomal protein L23, mitochondrial; FLJ45387; L23 mitochondrial-related protein; L23MRP; L23mt; mitochondrial ribosomal protein L23; MRP-L23; MRPL23; Ribosomal protein L23-like; ribosomal protein related to L23 (mitochondrial); RM23; RPL23; RPL23L
Gene Symbols: MRPL23
Molecular weight: 17,781 Da
Basal Isoelectric point: 9.69  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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