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LGR5 a leucine-rich repeat-containing G-protein-coupled receptor. Receptor for R-spondins, potent stimulators of adult stem cell proliferation. A marker of cycling, long-lived and multipotent adult stem cell populations. Target gene of Wnt signaling. A Wnt receptor component that enhances Wnt signaling by soluble R-spondin proteins. Intestinal Lgr5+ stem cells give rise throughout life to proliferation of cells in crypts, which migrate along the crypt-villus axis, differentiating into five main cell types. Wnt signaling plays a crucial role in the proliferation and differentiation of these crypt epithelial cells. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 12q21.1
Cellular Component: integral to plasma membrane; plasma membrane; trans-Golgi network membrane
Molecular Function: G-protein coupled receptor activity; protein binding; transmembrane receptor activity
Reference #:  O75473 (UniProtKB)
Alt. Names/Synonyms: FEX; G protein-coupled receptor 49; G protein-coupled receptor 67; G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38; GPR49; GPR67; GRP49; HG38; leucine-rich repeat-containing G protein-coupled receptor 5; Leucine-rich repeat-containing G-protein coupled receptor 5; LGR5; MGC117008; orphan G protein-coupled receptor HG38
Gene Symbols: LGR5
Molecular weight: 99,998 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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