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LAMP2 Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens. Defects in LAMP2 are the cause of Danon disease (DAND); also known as glycogen storage disease type 2B (GSD2B). DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes. Belongs to the LAMP family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: Xq24
Cellular Component: extracellular space; late endosome; late endosome membrane; lysosomal lumen; lysosomal membrane; lysosome; membrane; plasma membrane; platelet dense granule membrane
Molecular Function: enzyme binding; protein binding
Biological Process: cellular response to starvation; neutrophil degranulation; platelet degranulation; protein import; protein stabilization; protein targeting; regulation of protein stability
Disease: Danon Disease
Reference #:  P13473 (UniProtKB)
Alt. Names/Synonyms: CD107 antigen-like family member B; CD107b; LAMP-2; LAMP2; LAMPB; LGP110; lysosomal-associated membrane protein 2; Lysosome-associated membrane glycoprotein 2; Lysosome-associated membrane protein 2
Gene Symbols: LAMP2
Molecular weight: 44,961 Da
Basal Isoelectric point: 5.35  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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