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NHERF-2 Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus. Homodimer, and heterodimer with SLC9A3R1. Binds PDZK1. Found in a complex with EZR, PODXL and SLC9A3R2. Interacts (via the PDZ domains) with PODXL (via the C-terminal PDZ-binding motif DTHL); interaction is detected in glomerular epithelium cells. Binds ADRB2, SLC9A3, P2RY1, P2YR2, SRY, RDX and LPAR2. Interacts with MCC and PODXL. Interacts with SGK1 and KCNJ1/ROMK1. Widely expressed. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 10q12
Cellular Component: apical plasma membrane; cytoplasm; focal adhesion; nucleus; plasma membrane; protein complex; stereocilium; stereocilium bundle
Molecular Function: beta-catenin binding; cadherin binding; channel regulator activity; low-density lipoprotein receptor binding; PDZ domain binding; phosphatase binding; protein binding; protein C-terminus binding; protein complex scaffold; receptor binding
Biological Process: inner ear development; negative regulation of phosphoinositide 3-kinase cascade; positive regulation of membrane potential; sensory perception of sound
Reference #:  Q920G2 (UniProtKB)
Gene Symbols: Slc9a3r2
Molecular weight: 37,369 Da
Basal Isoelectric point: 7.25  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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