Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Cellular Component: cell soma; cell surface; cytoplasm; dendritic shaft; dendritic spine; endocytic vesicle; endosome; integral component of membrane; integral component of plasma membrane; membrane; neuron projection; plasma membrane
Molecular Function: G-protein alpha-subunit binding; G-protein coupled receptor activity; PDZ domain binding; phospholipid binding; protein binding; signal transducer activity
Biological Process: activation of MAPK activity; activation of phospholipase C activity; bleb formation; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); G-protein coupled receptor signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; negative regulation of cAMP biosynthetic process; positive regulation of apoptosis; positive regulation of MAPK cascade; positive regulation of Rho protein signal transduction; positive regulation of stress fiber formation; regulation of cell shape; signal transduction