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LPAR1 Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 4 B3|4 32.2 cM
Cellular Component: cell soma; cell surface; cytoplasm; dendritic shaft; dendritic spine; endocytic vesicle; endosome; integral component of membrane; integral component of plasma membrane; membrane; neuron projection; plasma membrane
Molecular Function: G-protein alpha-subunit binding; G-protein coupled receptor activity; PDZ domain binding; phospholipid binding; protein binding; signal transducer activity
Biological Process: activation of MAPK activity; activation of phospholipase C activity; bleb formation; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); G-protein coupled receptor signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; negative regulation of cAMP biosynthetic process; positive regulation of apoptosis; positive regulation of MAPK cascade; positive regulation of Rho protein signal transduction; positive regulation of stress fiber formation; regulation of cell shape; signal transduction
Reference #:  P61793 (UniProtKB)
Alt. Names/Synonyms: 5031439C20; AI326300; clone 4.9; Edg2; endothelial differentiation lysophosphatidic acid G-protein-coupled receptor 2; G-protein coupled receptor 26; Gpcr26; Kdt2; LPA receptor 1; LPA-1; Lpa1; Lpar1; Lysophosphatidic acid receptor 1; Lysophosphatidic acid receptor Edg-2; MGC29102; OTTMUSP00000008010; OTTMUSP00000008011; OTTMUSP00000008012; OTTMUSP00000008013; Rec1.3; VZG-1; Vzg1
Gene Symbols: Lpar1
Molecular weight: 41,119 Da
Basal Isoelectric point: 8.86  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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