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TLR3 a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. Most abundantly expressed in placenta and pancreas. Restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection. Acts via MyD88 and TRAF6, leading to the activation of NF-kappaB and the production of type I interferon. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 4q35.1
Cellular Component: cell surface; cytoplasm; endoplasmic reticulum membrane; endosome membrane; Golgi membrane; integral to plasma membrane; intracellular; lysosomal membrane
Molecular Function: double-stranded RNA binding; identical protein binding; protein binding; receptor activity
Biological Process: defense response to bacterium; defense response to virus; I-kappaB kinase/NF-kappaB cascade; I-kappaB phosphorylation; innate immune response; MyD88-independent toll-like receptor signaling pathway; negative regulation of MyD88-independent toll-like receptor signaling pathway; positive regulation of chemokine production; positive regulation of inflammatory response; positive regulation of interferon-alpha biosynthetic process; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-beta production; positive regulation of interferon-gamma biosynthetic process; positive regulation of interleukin-12 production; positive regulation of interleukin-6 production; positive regulation of interleukin-8 production; positive regulation of NF-kappaB import into nucleus; positive regulation of toll-like receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; response to exogenous dsRNA; signal transduction; toll-like receptor 3 signaling pathway; toll-like receptor signaling pathway
Disease: Human Immunodeficiency Virus Type 1, Susceptibility To
Reference #:  O15455 (UniProtKB)
Alt. Names/Synonyms: CD283; TLR3; Toll-like receptor 3
Gene Symbols: TLR3
Molecular weight: 103,829 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
CST Pathways:  NF-kB Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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