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CD3E a T cell surface glycoprotein that is a component of the T cell antigen receptor. The recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. Contains 1 immunoglobulin-like domain and 1 ITAM domain. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 9 A5.2|9 24.84 cM
Cellular Component: alpha-beta T cell receptor complex; cell body; dendritic spine; external side of plasma membrane; immunological synapse; integral component of membrane; intercellular junction; membrane; plasma membrane; T cell receptor complex
Molecular Function: protein binding; protein heterodimerization activity; protein homodimerization activity; SH3 domain binding; signal transducer activity; transmembrane receptor activity
Biological Process: adaptive immune response; cell surface receptor signaling pathway; cerebellum development; dendrite development; immune system process; lymphocyte activation; negative regulation of gene expression; negative regulation of smoothened signaling pathway; negative thymic T cell selection; positive regulation of alpha-beta T cell proliferation; positive regulation of calcium-mediated signaling; positive regulation of gene expression; positive regulation of interferon-gamma production; positive regulation of interleukin-2 biosynthetic process; positive regulation of interleukin-4 production; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of T cell activation; positive regulation of T cell anergy; positive regulation of T cell proliferation; protein homooligomerization; response to nutrient; T cell costimulation; T cell receptor signaling pathway
Reference #:  P22646 (UniProtKB)
Alt. Names/Synonyms: AI504783; CD3; CD3 antigen, epsilon polypeptide; Cd3e; CD3epsilon; OTTMUSP00000018104; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain; T3e
Gene Symbols: Cd3e
Molecular weight: 21,393 Da
Basal Isoelectric point: 6.72  Predict pI for various phosphorylation states
CST Pathways:  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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