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CHAT an enzyme that catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. Four alternative splice variants have been described. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; EC; Lipid Metabolism - glycerophospholipid
Chromosomal Location of Human Ortholog: 10q11.23
Cellular Component: cytoplasm; cytosol; nucleus; presynapse
Molecular Function: choline O-acetyltransferase activity
Biological Process: neurotransmitter biosynthetic process; neurotransmitter secretion; phosphatidylcholine biosynthetic process
Disease: Myasthenic Syndrome, Congenital, Associated With Episodic Apnea
Reference #:  P28329 (UniProtKB)
Alt. Names/Synonyms: acetyl CoA:choline O-acetyltransferase; CHAT; CHOACTase; Choline acetylase; choline acetyltransferase; Choline O-acetyltransferase; CLAT; CMS1A; CMS1A2
Gene Symbols: CHAT
Molecular weight: 82,536 Da
Basal Isoelectric point: 8.9  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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