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HRas a small GTPase protein of the Ras family. Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP). Mutations are implicated in a variety of human tumors. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 7 F5|7 86.48 cM
Cellular Component: Golgi apparatus; intracellular membrane-bound organelle; plasma membrane
Molecular Function: GDP binding; GTP binding; GTPase activity; protein binding; protein C-terminus binding
Biological Process: apoptosis; cell aging; cell cycle arrest; cell proliferation; defense response to protozoan; endocytosis; mitotic cell cycle checkpoint; negative regulation of cell proliferation; negative regulation of neuron apoptosis; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of epithelial cell proliferation; positive regulation of GTPase activity; positive regulation of interferon-gamma production; positive regulation of JNK cascade; positive regulation of MAP kinase activity; positive regulation of MAPKKK cascade; positive regulation of protein amino acid phosphorylation; positive regulation of Ras protein signal transduction; positive regulation of transcription from RNA polymerase II promoter; protein heterooligomerization; Ras protein signal transduction; regulation of long-term neuronal synaptic plasticity; small GTPase mediated signal transduction; T cell receptor signaling pathway; T-helper 1 type immune response
Reference #:  Q61411 (UniProtKB)
Alt. Names/Synonyms: c-H-ras; c-Ha-ras; c-Ha-ras p21 protein; c-Ha-ras transgene; c-rasHa; GTPase HRas; GTPase HRas, N-terminally processed; H-Ras; H-ras; H-ras 1 protein; H-Ras-1; Ha-ras; Harvey rat sarcoma virus oncogene 1; Harvey-ras; Hras; Hras-1; Hras1; Kras2; OTTMUSP00000017718; OTTMUSP00000017719; p21ras; ras; RASH; Transforming protein p21
Gene Symbols: Hras1
Molecular weight: 21,298 Da
Basal Isoelectric point: 5.16  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Angiogenesis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  NF-kB Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.
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