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ARRB2 a member of the arrestin/beta-arrestin protein family. These proteins participate in agonist-mediated desensitization of G-protein-coupled receptors. Acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Expressed at high levels in the CNS and peripheral blood leukocytes. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 17p13.2
Cellular Component: basolateral plasma membrane; clathrin-coated pit; cytoplasm; cytoplasmic vesicle; cytosol; dendritic spine; endocytic vesicle; intracellular membrane-bound organelle; nucleus; plasma membrane; postsynaptic density; postsynaptic membrane
Molecular Function: 14-3-3 protein binding; alpha-1A adrenergic receptor binding; alpha-1B adrenergic receptor binding; angiotensin receptor binding; D1 dopamine receptor binding; enzyme binding; follicle-stimulating hormone receptor binding; G-protein coupled receptor binding; identical protein binding; mitogen-activated protein kinase binding; platelet activating factor receptor binding; protein binding; protein complex binding; protein complex scaffold activity; protein domain specific binding; protein kinase B binding; receptor binding; type 1 angiotensin receptor binding; type 2A serotonin receptor binding; ubiquitin protein ligase binding
Biological Process: adult walking behavior; arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway; brain development; detection of temperature stimulus involved in sensory perception of pain; dopamine receptor signaling pathway; follicle-stimulating hormone signaling pathway; G-protein coupled receptor internalization; G-protein coupled receptor signaling pathway; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of interleukin-1 beta production; negative regulation of interleukin-12 production; negative regulation of interleukin-6 production; negative regulation of natural killer cell mediated cytotoxicity; negative regulation of NF-kappaB transcription factor activity; negative regulation of protein kinase B signaling cascade; negative regulation of protein phosphorylation; negative regulation of protein ubiquitination; negative regulation of release of cytochrome c from mitochondria; negative regulation of smooth muscle cell apoptotic process; negative regulation of toll-like receptor signaling pathway; negative regulation of tumor necrosis factor production; platelet activation; positive regulation of calcium ion transport; positive regulation of cardiac muscle cell differentiation; positive regulation of DNA biosynthetic process; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase B signaling; positive regulation of protein ubiquitination; positive regulation of receptor internalization; positive regulation of synaptic transmission, dopaminergic; proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; protein transport; protein ubiquitination; receptor internalization; transcription from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway
Reference #:  P32121 (UniProtKB)
Alt. Names/Synonyms: ARB2; ARR2; ARRB2; arrestin 3; Arrestin beta-2; arrestin, beta 2; BARR2; Beta-arrestin-2; DKFZp686L0365
Gene Symbols: ARRB2
Molecular weight: 46,106 Da
Basal Isoelectric point: 7.59  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Hedgehog Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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