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Protein Page:

SHIP-2 an SH2-containing inositol phosphatase. Recruited to activated receptor complexes including insulin R, PDGFR and Fc-gamma-R. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC; Motility/polarity/chemotaxis; Phosphatase, lipid
Chromosomal Location of Human Ortholog: 11q13.4
Cellular Component: cytosol; Golgi apparatus
Molecular Function: protein binding; SH2 domain binding
Biological Process: actin filament organization; cell adhesion; endochondral ossification; endocytosis; inositol phosphate metabolic process; phosphatidylinositol biosynthetic process
Disease: Opsismodysplasia
Reference #:  O15357 (UniProtKB)
Alt. Names/Synonyms: 51C protein; inositol polyphosphate phosphatase-like 1; Inositol polyphosphate phosphatase-like protein 1; INPPL-1; INPPL1; Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2; Protein 51C; SH2 domain-containing inositol phosphatase 2; SH2 domain-containing inositol-5'-phosphatase 2; SHIP-2; SHIP2
Gene Symbols: INPPL1
Molecular weight: 138,599 Da
Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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