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SPRY2 a feedback inhibitor of growth factor receptor signaling. Belongs to the sprouty family. May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor). Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Inhibitor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 13q31.1
Cellular Component: cytoskeleton; cytosol; membrane; microtubule cytoskeleton; nucleus; plasma membrane
Molecular Function: protein binding; protein kinase binding; protein serine/threonine kinase activator activity; protein serine/threonine kinase inhibitor activity
Biological Process: negative regulation of apoptosis; negative regulation of cell projection organization and biogenesis; negative regulation of epidermal growth factor receptor signaling pathway; positive regulation of cell migration; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein kinase B signaling cascade
Disease: Iga Nephropathy, Susceptibility To, 3
Reference #:  O43597 (UniProtKB)
Alt. Names/Synonyms: hSPRY2; MGC23039; Protein sprouty homolog 2; sprouty 2; sprouty homolog 2 (Drosophila); Spry-2; SPRY2; SPY2
Gene Symbols: SPRY2
Molecular weight: 34,688 Da
Basal Isoelectric point: 8.78  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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