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SPRY2 a feedback inhibitor of growth factor receptor signaling. Belongs to the sprouty family. May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor). Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Inhibitor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 13q31.1
Cellular Component: cytoskeleton; cytosol; membrane; microtubule; microtubule cytoskeleton; nucleus; plasma membrane
Molecular Function: protein binding; protein kinase binding; protein serine/threonine kinase activator activity; protein serine/threonine kinase inhibitor activity
Biological Process: cell fate commitment; establishment of mitotic spindle orientation; inner ear morphogenesis; negative regulation of apoptosis; negative regulation of cell projection organization; negative regulation of cell proliferation; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of ERK1 and ERK2 cascade; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of MAP kinase activity; negative regulation of neurotrophin TRK receptor signaling pathway; negative regulation of peptidyl-threonine phosphorylation; negative regulation of Ras protein signal transduction; positive regulation of cell migration; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein kinase B signaling; positive regulation of protein serine/threonine kinase activity; regulation of cell differentiation; sensory perception of sound
Disease: Iga Nephropathy, Susceptibility To, 3
Reference #:  O43597 (UniProtKB)
Alt. Names/Synonyms: hSPRY2; MGC23039; Protein sprouty homolog 2; sprouty 2; sprouty homolog 2 (Drosophila); Spry-2; SPRY2; SPY2
Gene Symbols: SPRY2
Molecular weight: 34,688 Da
Basal Isoelectric point: 8.78  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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