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Nik a protein kinase of the STE group of kinases. Binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE-Unique family
Chromosomal Location of Human Ortholog: 11 E1|11 66.8 cM
Cellular Component: cytoplasm; cytosol; fibrillar center; intracellular membrane-bound organelle; nucleus
Molecular Function: ATP binding; kinase activity; MAP kinase kinase kinase activity; NF-kappaB-inducing kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process: activation of protein kinase activity; defense response to virus; I-kappaB kinase/NF-kappaB signaling; immune response; phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; protein amino acid phosphorylation; regulation of apoptosis; regulation of mitotic cell cycle; stress-activated protein kinase signaling pathway
Reference #:  Q9WUL6 (UniProtKB)
Alt. Names/Synonyms: aly; alymphoplasia; M3K14; Map3k14; Mitogen-activated protein kinase kinase kinase 14; NF kappa B-inducing kinase; NF-kappa-beta-inducing kinase; Nfkb inducing kinase; Nik; OTTMUSP00000002951; protein kinase; Serine/threonine-protein kinase NIK
Gene Symbols: Map3k14
Molecular weight: 103,080 Da
Basal Isoelectric point: 7.34  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Apoptosis Regulation  |  B Cell Receptor Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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