a protein kinase of the STE group of kinases. Binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. Note: This description may include information from UniProtKB.
Protein type: EC 22.214.171.124; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE-Unique family
Molecular Function: ATP binding; kinase activity; MAP kinase kinase kinase activity; NF-kappaB-inducing kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process: activation of protein kinase activity; defense response to virus; I-kappaB kinase/NF-kappaB signaling; immune response; phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; protein amino acid phosphorylation; regulation of apoptosis; regulation of mitotic cell cycle; stress-activated protein kinase signaling pathway