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GluR4 an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA(quisqualate) > glutamate > kainate. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. Note: This description may include information from UniProtKB.
Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11q22.3
Cellular Component: cell junction; cell soma; dendritic spine; plasma membrane; postsynaptic membrane
Molecular Function: AMPA glutamate receptor activity; excitatory extracellular ligand-gated ion channel activity; extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor activity
Biological Process: excitatory postsynaptic potential; glutamate receptor signaling pathway; ionotropic glutamate receptor signaling pathway; transport
Reference #:  P48058 (UniProtKB)
Alt. Names/Synonyms: AMPA-selective glutamate receptor 4; GluR-4; GluR-D; GLUR4; GLUR4C; GLURD; Glutamate receptor 4; Glutamate receptor ionotropic, AMPA 4; glutamate receptor, ionotrophic, AMPA 4; GRIA4
Gene Symbols: GRIA4
Molecular weight: 100,871 Da
Basal Isoelectric point: 8.32  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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