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CYP46A1 Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. Belongs to the cytochrome P450 family. Note: This description may include information from UniProtKB.
Protein type: EC; Lipid Metabolism - primary bile acid biosynthesis; Membrane protein, integral; Oxidoreductase
Chromosomal Location of Human Ortholog: 14q32.2
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane
Molecular Function: cholesterol 24-hydroxylase activity; heme binding; steroid hydroxylase activity
Biological Process: bile acid biosynthetic process; cholesterol catabolic process; nervous system development; sterol metabolic process; xenobiotic metabolic process
Reference #:  Q9Y6A2 (UniProtKB)
Alt. Names/Synonyms: CH24H; Cholesterol 24-hydroxylase; CP46; CP46A; CYP46; CYP46A1; Cytochrome P450 46A1; cytochrome P450, family 46; cytochrome P450, family 46, subfamily A, polypeptide 1; cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase)
Gene Symbols: CYP46A1
Molecular weight: 56,821 Da
Basal Isoelectric point: 9.15  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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