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CALCOCO1 Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1- mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions. Belongs to the CALCOCO family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component: cytosol; intracellular membrane-bound organelle; nucleus
Molecular Function: beta-catenin binding; ligand-dependent nuclear receptor transcription coactivator activity; protein binding; protein C-terminus binding; sequence-specific DNA binding; transcription coactivator activity; transcription cofactor activity
Biological Process: positive regulation of transcription, DNA-dependent; signal transduction; steroid hormone receptor signaling pathway; transcription, DNA-dependent
Reference #:  Q9P1Z2 (UniProtKB)
Alt. Names/Synonyms: CACO1; calcium binding and coiled-coil domain 1; Calcium-binding and coiled-coil domain-containing protein 1; CALCOCO1; Calphoglin; Cocoa; Coiled-coil coactivator protein; coiled-coil leucine zipper coactivator 1; inorganic pyrophosphatase activator; KIAA1536; PP13275; Sarcoma antigen NY-SAR-3
Gene Symbols: CALCOCO1
Molecular weight: 77,336 Da
Basal Isoelectric point: 4.77  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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