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IL10 Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. Belongs to the IL-10 family. Note: This description may include information from UniProtKB.
Protein type: Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1 E4|1 56.89 cM
Cellular Component: extracellular region; extracellular space
Molecular Function: cytokine activity; interleukin-10 receptor binding
Biological Process: defense response to bacterium; defense response to protozoan; immune response; inflammatory response; negative regulation of apoptosis; negative regulation of B cell proliferation; negative regulation of cell proliferation; negative regulation of chronic inflammatory response to antigenic stimulus; negative regulation of cytokine production; negative regulation of cytokine secretion involved in immune response; negative regulation of heterotypic cell-cell adhesion; negative regulation of inflammatory response; negative regulation of interferon-gamma production; negative regulation of interleukin-12 production; negative regulation of interleukin-6 production; negative regulation of membrane protein ectodomain proteolysis; negative regulation of myeloid dendritic cell activation; negative regulation of nitric oxide biosynthetic process; negative regulation of tumor necrosis factor biosynthetic process; negative regulation of tumor necrosis factor production; positive regulation of B cell apoptotic process; positive regulation of cell cycle; positive regulation of cytokine secretion; positive regulation of endothelial cell proliferation; positive regulation of macrophage activation; positive regulation of MHC class II biosynthetic process; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; receptor biosynthetic process; regulation of gene expression; regulation of sensory perception of pain; regulation of synapse organization; response to glucocorticoid stimulus; response to molecule of bacterial origin
Reference #:  P18893 (UniProtKB)
Alt. Names/Synonyms: CSIF; Cytokine synthesis inhibitory factor; IL-10; Il10; interleukin 10; Interleukin-10; OTTMUSP00000017964
Gene Symbols: Il10
Molecular weight: 20,641 Da
Basal Isoelectric point: 8.45  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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