Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase. Defects in GNAT2 are the cause of achromatopsia type 4 (ACHM4). Achromatopsia is an autosomal recessively inherited visual disorder that is present from birth and that features the absence of color discrimination. Belongs to the G-alpha family. G(i/o/t/z) subfamily. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z))
Molecular Function: G-protein beta/gamma-subunit complex binding; G-protein coupled photoreceptor activity; G-protein coupled receptor binding; GTP binding; GTPase activity; metal ion binding; signal transducer activity
Biological Process: detection of chemical stimulus involved in sensory perception of bitter taste; detection of light stimulus involved in visual perception; elevation of cytosolic calcium ion concentration; G-protein coupled receptor signaling pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; phototransduction; protein folding; response to light intensity; retinal cone cell development; visual perception; Wnt receptor signaling pathway, calcium modulating pathway