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FADS3 is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. [provided by RefSeq, Jul 2008]
Protein type: EC 1.14.19.-; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase
Chromosomal Location of Human Ortholog: 11q12.2
Cellular Component: endoplasmic reticulum membrane; integral component of membrane; membrane
Molecular Function: oxidoreductase activity
Biological Process: unsaturated fatty acid biosynthetic process
Reference #:  Q9Y5Q0 (UniProtKB)
Alt. Names/Synonyms: CYB5RP; Cytochrome b5-related protein; delta-9 fatty acid desaturase; delta-9-desaturase; FADS3; Fatty acid desaturase 3; linoleoyl-CoA desaturase (delta-9-desaturase)-like 3; LLCDL3
Gene Symbols: FADS3
Molecular weight: 51,145 Da
Basal Isoelectric point: 7.42  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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