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HCN1 Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. May mediate responses to sour stimuli. Belongs to the potassium channel HCN family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 5p12
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: cAMP binding; intracellular cAMP activated cation channel activity; voltage-gated cation channel activity; voltage-gated potassium channel activity; voltage-gated sodium channel activity
Biological Process: protein homotetramerization; regulation of membrane potential
Disease: Epileptic Encephalopathy, Early Infantile, 24
Reference #:  O60741 (UniProtKB)
Alt. Names/Synonyms: BCNG-1; BCNG1; brain cyclic nucleotide gated channel 1; Brain cyclic nucleotide-gated channel 1; HAC-2; HCN1; hyperpolarization activated cyclic nucleotide-gated potassium channel 1; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Gene Symbols: HCN1
Molecular weight: 98,796 Da
Basal Isoelectric point: 8.63  Predict pI for various phosphorylation states
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