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CNOT6 Poly(A) nuclease involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. Has 3'-5' RNase activity. The CCR4-NOT complex functions as general transcription regulation complex. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Belongs to the CCR4/nocturin family. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase
Chromosomal Location of Human Ortholog: 5q35.3
Cellular Component: CCR4-NOT complex; cytosol; membrane
Molecular Function: exoribonuclease activity; poly(A)-specific ribonuclease activity; protein binding
Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; miRNA-mediated gene silencing; poly(A) tail shortening; positive regulation of cell proliferation
Reference #:  Q9ULM6 (UniProtKB)
Alt. Names/Synonyms: carbon catabolite repression 4 protein; Carbon catabolite repressor protein 4 homolog; CCR4; CCR4 carbon catabolite repression 4-like; CCR4-NOT transcription complex subunit 6; CCR4-NOT transcription complex, subunit 6; CNOT6; Cytoplasmic deadenylase; KIAA1194
Gene Symbols: CNOT6
Molecular weight: 63,307 Da
Basal Isoelectric point: 6.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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