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MGLL Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth. Belongs to the AB hydrolase superfamily. Monoacylglycerol lipase family. Note: This description may include information from UniProtKB.
Protein type: EC; Lipid Metabolism - glycerolipid; Phospholipase
Chromosomal Location of Human Ortholog: 3q21.3
Cellular Component: cytosol; endoplasmic reticulum membrane; extrinsic to membrane; membrane; nucleoplasm; plasma membrane
Molecular Function: acylglycerol lipase activity; lysophospholipase activity; protein homodimerization activity
Biological Process: acylglycerol catabolic process; arachidonic acid metabolic process; inflammatory response; lipid metabolic process; regulation of inflammatory response; regulation of sensory perception of pain; regulation of signal transduction
Reference #:  Q99685 (UniProtKB)
Alt. Names/Synonyms: HU-K5; HUK5; Lysophospholipase homolog; Lysophospholipase-like; MAGL; MGL; MGLL; monoacylglycerol lipase; Monoglyceride lipase
Gene Symbols: MGLL
Molecular weight: 33,261 Da
Basal Isoelectric point: 6.49  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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