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CYBA Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. Defects in CYBA are a cause of chronic granulomatous disease autosomal recessive cytochrome-b-negative (ARCGD). Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections. Belongs to the p22phox family. Note: This description may include information from UniProtKB.
Protein type: EC 1.-.-.-; Membrane protein, integral; Oxidoreductase
Chromosomal Location of Human Ortholog: 16q24.2
Cellular Component: apical plasma membrane; cell soma; dendrite; endoplasmic reticulum membrane; endosome; focal adhesion; Golgi apparatus; membrane; mitochondrion; NADPH oxidase complex; nucleus; phagocytic vesicle membrane; plasma membrane; secretory granule; stress fiber
Molecular Function: electron transfer activity; heme binding; metal ion binding; protein binding; protein heterodimerization activity; SH3 domain binding; superoxide-generating NADPH oxidase activity
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cell redox homeostasis; cytochrome complex assembly; hydrogen peroxide biosynthetic process; inflammatory response; innate immune response; negative regulation of glomerular filtration by angiotensin; neutrophil degranulation; positive regulation of cell growth; positive regulation of endothelial cell proliferation; positive regulation of interleukin-6 production; positive regulation of NAD(P)H oxidase activity; positive regulation of phagocytosis; positive regulation of smooth muscle cell proliferation; positive regulation of superoxide anion generation; positive regulation of toll-like receptor 2 signaling pathway; positive regulation of tumor necrosis factor production; regulation of release of sequestered calcium ion into cytosol; respiratory burst; response to activity; response to drug; response to hypoxia; response to nutrient levels; smooth muscle hypertrophy; superoxide anion generation; superoxide metabolic process; vascular endothelial growth factor receptor signaling pathway
Disease: Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-negative
Reference #:  P13498 (UniProtKB)
Alt. Names/Synonyms: CY24A; CYBA; cytochrome b light chain; Cytochrome b(558) alpha chain; cytochrome b(558) alpha-subunit; cytochrome b, alpha polypeptide; Cytochrome b-245 light chain; cytochrome b-245, alpha polypeptide; Cytochrome b558 subunit alpha; flavocytochrome b-558 alpha polypeptide; Neutrophil cytochrome b 22 kDa polypeptide; p22 phagocyte B-cytochrome; p22-phox; p22phox; Superoxide-generating NADPH oxidase light chain subunit
Gene Symbols: CYBA
Molecular weight: 21,013 Da
Basal Isoelectric point: 9.58  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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