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CARD14 a protein containing a caspase recruitment domain (CARD) that functions as an activator of BCL10 and NF-kappaB signaling. CARD is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in signaling through highly specific protein-protein homophilic interactions. CARD proteins function as scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. The CARD domain of CARD14 associates specifically with the CARD domains of CARD10 and BCL10, a signaling protein that activates NF-kB through the IkappaB kinase complex in response to upstream stimuli. When expressed in cells, CARD14 activates NF-kappaB and induces the phosphorylation of BCL10. A subgroup of primary lymphomas of the central nervous system have higher levels of CARD14 expression. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: cytoplasm
Molecular Function: CARD domain binding
Biological Process: activation of NF-kappaB transcription factor; negative regulation of apoptosis; positive regulation of protein amino acid phosphorylation; tumor necrosis factor-mediated signaling pathway
Disease: Pityriasis Rubra Pilaris; Psoriasis 2
Reference #:  Q9BXL6 (UniProtKB)
Alt. Names/Synonyms: bcl10-interacting maguk protein 2; BIMP2; CAR14; CARD-containing MAGUK 2 protein; CARD-containing MAGUK protein 2; card-maguk protein 2; CARD14; Carma 2; CARMA2; caspase recruitment domain family, member 14; Caspase recruitment domain-containing protein 14
Gene Symbols: CARD14
Molecular weight: 113,270 Da
Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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