a protein containing a caspase recruitment domain (CARD) that functions as an activator of BCL10 and NF-kappaB signaling. CARD is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in signaling through highly specific protein-protein homophilic interactions. CARD proteins function as scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. The CARD domain of CARD14 associates specifically with the CARD domains of CARD10 and BCL10, a signaling protein that activates NF-kB through the IkappaB kinase complex in response to upstream stimuli. When expressed in cells, CARD14 activates NF-kappaB and induces the phosphorylation of BCL10. A subgroup of primary lymphomas of the central nervous system have higher levels of CARD14 expression. Note: This description may include information from UniProtKB.
Alt. Names/Synonyms: bcl10-interacting maguk protein 2; BIMP2; CAR14; CARD-containing MAGUK 2 protein; CARD-containing MAGUK protein 2; card-maguk protein 2; CARD14; Carma 2; CARMA2; caspase recruitment domain family, member 14; Caspase recruitment domain-containing protein 14