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MMP20 Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Defects in MMP20 are the cause of amelogenesis imperfecta hypomaturation type 2A2 (AI2A2). AI2A2 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel. Belongs to the peptidase M10A family. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.24.-; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11q22.2
Cellular Component: extracellular region; extracellular space; proteinaceous extracellular matrix
Molecular Function: metalloendopeptidase activity; protein binding; serine-type endopeptidase activity; zinc ion binding
Biological Process: collagen catabolic process; extracellular matrix disassembly; protein catabolic process; proteolysis
Disease: Amelogenesis Imperfecta, Hypomaturation Type, Iia2
Reference #:  O60882 (UniProtKB)
Alt. Names/Synonyms: AI2A2; Enamel metalloproteinase; Enamelysin; matrix metallopeptidase 20; matrix metalloproteinase 20 (enamelysin); Matrix metalloproteinase-20; MMP-20; MMP20
Gene Symbols: MMP20
Molecular weight: 54,387 Da
Basal Isoelectric point: 8.92  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  GPCR Signaling to MAPKs
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Protein Structure Not Found.
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