an atypical protein kinase that functions as a transcriptional coactivator. Mediates transcriptional regulation by interaction with the Kruppel-associated box (KRAB) repression domain found in many transcription factors. Binds to the negative regulatory domain of c-Myb and negatively regulates the c-Myb-dependent trans-activation. Localizes to the nucleus and is thought to associate with specific chromatin regions. Phosphorylated in an ATM-dependent manner following double-strand breaks. Its phosphorylation in response to DNA damage leads to chromatin relaxation. A member of the tripartite motif family. The tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Note: This description may include information from UniProtKB.
Molecular Function: chromatin binding; chromo shadow domain binding; DNA binding; DNA binding transcription factor activity; promoter-specific chromatin binding; protein binding; protein kinase activity; RNA binding; sequence-specific DNA binding; transcription corepressor activity; ubiquitin protein ligase binding; ubiquitin-protein transferase activity; zinc ion binding
Biological Process: convergent extension involved in axis elongation; covalent chromatin modification; DNA methylation involved in embryo development; DNA repair; embryo implantation; epithelial to mesenchymal transition; innate immune response; negative regulation of DNA demethylation; negative regulation of retroviral genome replication; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of viral release from host cell; positive regulation of DNA binding; positive regulation of DNA repair; positive regulation of methylation-dependent chromatin silencing; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; protein autophosphorylation; protein oligomerization; protein sumoylation; protein ubiquitination; Ras protein signal transduction; regulation of genetic imprinting; transcription initiation from RNA polymerase II promoter