Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

TIF1B an atypical protein kinase that functions as a transcriptional coactivator. Mediates transcriptional regulation by interaction with the Kruppel-associated box (KRAB) repression domain found in many transcription factors. Binds to the negative regulatory domain of c-Myb and negatively regulates the c-Myb-dependent trans-activation. Localizes to the nucleus and is thought to associate with specific chromatin regions. Phosphorylated in an ATM-dependent manner following double-strand breaks. Its phosphorylation in response to DNA damage leads to chromatin relaxation. A member of the tripartite motif family. The tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; EC 6.3.2.-; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; TIF1 family; Transcription, coactivator/corepressor; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 19q13.43
Cellular Component: nuclear euchromatin; nuclear heterochromatin; nucleoplasm; nucleus; RNA polymerase II transcription factor complex
Molecular Function: chromatin binding; chromo shadow domain binding; DNA binding; DNA binding transcription factor activity; promoter-specific chromatin binding; protein binding; protein kinase activity; RNA binding; sequence-specific DNA binding; transcription corepressor activity; ubiquitin protein ligase binding; ubiquitin-protein transferase activity; zinc ion binding
Biological Process: convergent extension involved in axis elongation; covalent chromatin modification; DNA methylation involved in embryo development; DNA repair; embryo implantation; epithelial to mesenchymal transition; innate immune response; negative regulation of DNA demethylation; negative regulation of retroviral genome replication; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of viral release from host cell; positive regulation of DNA binding; positive regulation of DNA repair; positive regulation of methylation-dependent chromatin silencing; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; protein autophosphorylation; protein oligomerization; protein sumoylation; protein ubiquitination; Ras protein signal transduction; regulation of genetic imprinting; transcription initiation from RNA polymerase II promoter
Reference #:  Q13263 (UniProtKB)
Alt. Names/Synonyms: FLJ29029; KAP-1; KAP1; KRAB-associated protein 1; KRAB-interacting protein 1; KRIP-1; Nuclear corepressor KAP-1; RING finger protein 96; RNF96; TF1B; TIF1-beta; TIF1B; Transcription intermediary factor 1-beta; transcriptional intermediary factor 1-beta; TRIM28; tripartite motif-containing 28; Tripartite motif-containing protein 28
Gene Symbols: TRIM28
Molecular weight: 88,550 Da
Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  KinBase  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA