Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

EIF3K Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Belongs to the eIF-3 subunit K family. Note: This description may include information from UniProtKB.
Protein type: Translation; Translation initiation
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: cytosol; eukaryotic translation initiation factor 3 complex; membrane
Molecular Function: protein binding; translation initiation factor activity
Biological Process: translational initiation
Reference #:  Q9UBQ5 (UniProtKB)
Alt. Names/Synonyms: ARG134; eIF-3 p25; eIF-3 p28; EIF3-p28; EIF3K; EIF3S12; Eukaryotic translation initiation factor 3 subunit 12; Eukaryotic translation initiation factor 3 subunit K; eukaryotic translation initiation factor 3, subunit 12; eukaryotic translation initiation factor 3, subunit K; HSPC029; M9; MSTP001; muscle specific; Muscle-specific gene M9 protein; PLAC-24; PLAC24; PRO1474; PTD001
Gene Symbols: EIF3K
Molecular weight: 25,060 Da
Basal Isoelectric point: 4.81  Predict pI for various phosphorylation states
CST Pathways:  Translational Control
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene