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Protein Page:
TYKY

Overview
TYKY Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May donate electrons to ubiquinone. Defects in NDUFS8 are a cause of Leigh syndrome (LS). LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions. Belongs to the complex I 23 kDa subunit family. Note: This description may include information from UniProtKB.
Protein type: EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase
Chromosomal Location of Human Ortholog: 19|19 A
Cellular Component: membrane; mitochondrial respiratory chain complex I; mitochondrion
Molecular Function: 4 iron, 4 sulfur cluster binding; iron-sulfur cluster binding; metal ion binding; NADH dehydrogenase (ubiquinone) activity; NADH dehydrogenase activity; oxidoreductase activity; oxidoreductase activity, acting on NADH or NADPH
Biological Process: mitochondrial respiratory chain complex I assembly; response to oxidative stress; transport
Reference #:  Q8K3J1 (UniProtKB)
Alt. Names/Synonyms: BC021616; CI-23kD; Complex I-23kD; MGC101957; MGC37950; NADH dehydrogenase (ubiquinone) Fe-S protein 8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial; NADH-ubiquinone oxidoreductase 23 kDa subunit; Ndufs8; NDUS8; TYKY
Gene Symbols: Ndufs8
Molecular weight: 24,038 Da
Basal Isoelectric point: 5.89  Predict pI for various phosphorylation states
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TYKY

Protein Structure Not Found.
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