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SDH5 a subunit of succinate dehydrogenase (SDH) complex II of the mitochondrial electron transport chain. SDH5 is required for insertion of FAD cofactor into SDHA, the catalytic subunit of succinate dehydrogenase (SDH) complex II. SDH is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Mutated in some cancers. Germline mutations cause hereditary paragangliomas type 2, or non-chromaffin paragangliomas type 2. Paragangliomas are rare tumors that arise from components of the neuroendocrine system. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 11q12.2
Cellular Component: cytosol; mitochondrial matrix; mitochondrion; nucleolus
Molecular Function: protein binding
Biological Process: mitochondrial electron transport, succinate to ubiquinone; protein amino acid dephosphorylation; protein-FAD linkage; tricarboxylic acid cycle
Disease: Paragangliomas 2
Reference #:  Q9NX18 (UniProtKB)
Alt. Names/Synonyms: C11orf79; FLJ20487; hSDH5; paraganglioma or familial glomus tumors 2; PGL2; SDH assembly factor 2; SDH5; SDHAF2; SDHF2; Succinate dehydrogenase assembly factor 2, mitochondrial; succinate dehydrogenase complex assembly factor 2; Succinate dehydrogenase subunit 5, mitochondrial
Gene Symbols: SDHAF2
Molecular weight: 19,599 Da
Basal Isoelectric point: 6.33  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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