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XRCC3 Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C. Defects in XRCC3 are the cause of susceptibility to breast cancer (BC). BC is a common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case. Defects in XRCC3 are the cause of susceptibility to cutaneous malignant melanoma type 6 (CMM6). CMM6 is a malignant neoplasm of melanocytes, arising de novo or from a pre- existing benign nevus, which occurs most often in the skin but also may involve other sites. Belongs to the RecA family. RAD51 subfamily. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage
Chromosomal Location of Human Ortholog: 14q32.33
Cellular Component: cytoplasm; cytosol; mitochondrion; nuclear chromosome, telomeric region; nucleoplasm; nucleus; perinuclear region of cytoplasm; replication fork
Molecular Function: crossover junction endodeoxyribonuclease activity; DNA-dependent ATPase activity; double-stranded DNA binding; four-way junction DNA binding; protein binding; recombinase activity; single-stranded DNA binding
Biological Process: DNA recombination; DNA repair; DNA synthesis during DNA repair; double-strand break repair via homologous recombination; meiotic DNA recombinase assembly; meiotic recombination; response to DNA damage stimulus; response to ionizing radiation; strand displacement; strand invasion; telomere maintenance via recombination
Disease: Breast Cancer; Melanoma, Cutaneous Malignant, Susceptibility To, 6
Reference #:  O43542 (UniProtKB)
Alt. Names/Synonyms: DNA repair protein XRCC3; RAD51-like; X-ray repair complementing defective repair in Chinese hamster cells 3; X-ray repair cross complementing protein 3; X-ray repair cross-complementing protein 3; XRCC3
Gene Symbols: XRCC3
Molecular weight: 37,850 Da
Basal Isoelectric point: 8.81  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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