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SLC26A3 Chloride/bicarbonate exchanger. Mediates the efficient absorbtion of chloride ions in the colon, participating in fluid homeostasis. Defects in SLC26A3 are the cause of diarrhea type 1 (DIAR1); also known as congenital chloride diarrhea (CLD). DIAR1 is a disease characterized by voluminous watery stools containing an excess of chloride. The children with this disease are often premature. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 7q22.3-q31.1
Cellular Component: integral to plasma membrane; membrane; plasma membrane
Molecular Function: anion:anion antiporter activity; bicarbonate transmembrane transporter activity; chloride channel activity; chloride transmembrane transporter activity; inorganic anion exchanger activity; oxalate transmembrane transporter activity; protein binding; sulfate transmembrane transporter activity; transcription cofactor activity; transcription factor activity; transporter activity
Biological Process: anion transport; bicarbonate transport; excretion; intracellular pH elevation; ion transport; membrane hyperpolarization; regulation of intracellular pH; regulation of membrane potential; sperm capacitation
Disease: Diarrhea 1, Secretory Chloride, Congenital
Reference #:  P40879 (UniProtKB)
Alt. Names/Synonyms: Chloride anion exchanger; CLD; Down-regulated in adenoma; down-regulated in adenoma protein; DRA; Protein DRA; S26A3; SLC26A3; Solute carrier family 26 member 3; solute carrier family 26, member 3
Gene Symbols: SLC26A3
Molecular weight: 84,505 Da
Basal Isoelectric point: 8.87  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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