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Protein Page:

PIK3R4 Regulatory subunit of the PI3K complex. May regulate membrane trafficking late in the endocytic pathway. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, lipid; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); VPS15 family
Chromosomal Location of Human Ortholog: 3q22.1
Cellular Component: axoneme; cytosol; intracellular membrane-bound organelle; late endosome; membrane; microtubule cytoskeleton; nuclear pore; phagocytic vesicle membrane
Molecular Function: 1-phosphatidylinositol-3-kinase activity; protein binding; protein serine/threonine kinase activity
Biological Process: cellular response to glucose starvation; late endosome to vacuole transport; macroautophagy; peroxisome degradation; phosphatidylinositol biosynthetic process; positive regulation of phosphoinositide 3-kinase activity; protein amino acid phosphorylation; protein targeting to vacuole; receptor catabolic process; regulation of cytokinesis; toll-like receptor 9 signaling pathway
Reference #:  Q99570 (UniProtKB)
Alt. Names/Synonyms: MGC102700; p150; phosphatidylinositol 3-kinase-associated p150; Phosphoinositide 3-kinase adaptor protein; Phosphoinositide 3-kinase regulatory subunit 4; phosphoinositide-3-kinase, regulatory subunit 4; phosphoinositide-3-kinase, regulatory subunit 4, p150; PI3-kinase p150 subunit; PI3-kinase regulatory subunit 4; PI3R4; PIK3R4; VPS15
Gene Symbols: PIK3R4
Molecular weight: 153,103 Da
Basal Isoelectric point: 6.74  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  AMPK Signaling  |  Angiogenesis  |  Apoptosis Regulation  |  Autophagy Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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