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PDZD3 Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: apical part of cell; brush border; cytosol; subapical complex
Molecular Function: guanylate cyclase inhibitor activity; ion channel inhibitor activity; protein binding; protein C-terminus binding
Biological Process: negative regulation of cGMP biosynthetic process; receptor guanylyl cyclase signaling pathway; response to toxin
Reference #:  Q86UT5 (UniProtKB)
Alt. Names/Synonyms: FLJ22756; IKEPP; intestinal and kidney enriched PDZ protein; Intestinal and kidney-enriched PDZ protein; Na(+)/H(+) exchange regulatory cofactor NHE-RF4; Na/Pi cotransporter C-terminal-associated protein 2; NaPi-Cap2; Natrium-phosphate cotransporter IIa C-terminal-associated protein 2; NHERF-4; NHERF4; NHRF4; PDZ domain containing 2; PDZ domain containing 3; PDZ domain-containing protein 2; PDZ domain-containing protein 3; PDZD3; PDZK2; Sodium-hydrogen exchanger regulatory factor 4
Gene Symbols: PDZD3
Molecular weight: 61,032 Da
Basal Isoelectric point: 6.24  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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