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ATG12 Ubiquitin-like protein required for autophagy. Conjugated to ATG3 and ATG5. Ubiquitous. Belongs to the ATG12 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Ubiquitin-like modifier
Chromosomal Location of Human Ortholog: 5q22.3
Cellular Component: autophagic vacuole; cytosol; phagocytic vesicle membrane; pre-autophagosomal structure membrane
Molecular Function: Atg8 ligase activity; protein binding
Biological Process: autophagosome assembly; C-terminal protein lipidation; innate immune response; macroautophagy; mitochondrion degradation
Reference #:  O94817 (UniProtKB)
Alt. Names/Synonyms: APG12; Apg12 (autophagy, yeast) homolog; APG12 autophagy 12-like; APG12-like; APG12L; ATG12; ATG12 autophagy related 12 homolog (S. cerevisiae); Autophagy-related protein 12; FBR93; HAPG12
Gene Symbols: ATG12
Molecular weight: 15,113 Da
Basal Isoelectric point: 5.01  Predict pI for various phosphorylation states
CST Pathways:  Autophagy Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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