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TECTA One of the major non-collagenous components of the tectorial membrane. The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Defects in TECTA are the cause of deafness autosomal dominant type 12 (DFNA12); also known as DFNA8. DFNA12 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Defects in TECTA are the cause of deafness autosomal recessive type 21 (DFNB21). Note: This description may include information from UniProtKB.
Protein type: Extracellular matrix; Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: extracellular region; plasma membrane
Biological Process: C-terminal protein lipidation
Disease: Deafness, Autosomal Dominant 12; Deafness, Autosomal Recessive 21
Reference #:  O75443 (UniProtKB)
Alt. Names/Synonyms: Alpha-tectorin; DFNA12; DFNA8; DFNB21; TECTA; tectorin alpha
Gene Symbols: TECTA
Molecular weight: 239,527 Da
Basal Isoelectric point: 5.23  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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