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TICAM1 an adaptor protein involved in innate immunity against invading pathogens. Associates with TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TICAM1 recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Interacts with the TIR domain of TLR3. Interacts with AZI2, TBK1, IRF3 and IRF7. Interacts with TICAM2 in TLR4 recruitment. Interaction with PIAS4 inhibits the TICAM1-induced NF-kappa-B, IRF and IFNB1 activation. Interacts with IKBKB and IKBKE. Interaction with SARM1 blocks TICAM1-dependent transcription factor activation. Interacts with TRAF3. Interacts with TRAFD1. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Apoptosis
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: autophagic vacuole; cytosol; endosome membrane
Molecular Function: protein binding; protein kinase binding; signal transducer activity
Biological Process: defense response to virus; I-kappaB kinase/NF-kappaB signaling; inflammatory response; innate immune response; lipopolysaccharide-mediated signaling pathway; macrophage activation involved in immune response; MyD88-independent toll-like receptor signaling pathway; negative regulation of MyD88-independent toll-like receptor signaling pathway; positive regulation of autophagy; positive regulation of B cell proliferation; positive regulation of chemokine biosynthetic process; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interferon-beta biosynthetic process; positive regulation of interleukin-6 production; positive regulation of natural killer cell activation; positive regulation of NF-kappaB transcription factor activity; positive regulation of nitric oxide biosynthetic process; positive regulation of protein binding; positive regulation of protein ubiquitination; positive regulation of tumor necrosis factor production; regulation of protein homodimerization activity; response to exogenous dsRNA
Disease: Herpes Simplex Encephalitis, Susceptibility To, 4
Reference #:  Q8IUC6 (UniProtKB)
Alt. Names/Synonyms: MGC35334; Proline-rich, vinculin and TIR domain-containing protein B; PRVTIRB; Putative NF-kappa-B-activating protein 502H; TCAM1; TICAM-1; TICAM1; TIR domain containing adaptor inducing interferon-beta; TIR domain-containing adapter molecule 1; TIR domain-containing adapter protein inducing IFN-beta; TIR domain-containing adaptor molecule 1; Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta; toll-like receptor adaptor molecule 1; TRIF
Gene Symbols: TICAM1
Molecular weight: 76,422 Da
Basal Isoelectric point: 5.24  Predict pI for various phosphorylation states
CST Pathways:  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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