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CCR5 a 7-transmembrane G-linked receptor for a number of inflammatory C-C type chemokines including MIP-1-alpha, MIP-1-beta and RANTES. Transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (along with CD4) for HIV-1 R5 isolates. Interacts with PRAF2. Interacts with HIV-1 surface protein gp120. Efficient ligand binding to CCL3/MIP-1alpha and CCR4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on S6 is required for efficient binding of CCL4. Interacts with ADRBK1. Interacts with ARRB1 and ARRB2. Variations in CCR5 are associated with resistance or susceptibility to immunodeficiency virus type 1 (resistance or susceptibility to HIV-1). Variations in CCR5 gene also influence the rate of progression to AIDS after infection. R60S variant, a naturally occurring mutation in a conserved residue in the first intracellular domain of CCR5, results in reduced amounts of the protein in the membrane and consequently may be associated with reduced susceptibility to infection by microbes that depend on these molecules as their receptors. Variations in CCR5 are associated with susceptibility to West Nile virus (WNV) infection Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR; Receptor, cytokine
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component: cell surface; cytoplasm; endosome; external side of plasma membrane; integral to plasma membrane; plasma membrane
Molecular Function: actin binding; C-C chemokine binding; C-C chemokine receptor activity; chemokine receptor activity; coreceptor activity; phosphoinositide phospholipase C activity; protein binding
Biological Process: calcium ion transport; calcium-mediated signaling; cell surface receptor linked signal transduction; cell-cell signaling; cellular defense response; chemotaxis; dendritic cell chemotaxis; elevation of cytosolic calcium ion concentration; entry into host cell; G-protein coupled receptor protein signaling pathway; MAPKKK cascade; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; viral envelope fusion with host membrane
Disease: Diabetes Mellitus, Insulin-dependent, 22; Hepatitis C Virus, Susceptibility To; West Nile Virus, Susceptibility To
Reference #:  P51681 (UniProtKB)
Alt. Names/Synonyms: C-C chemokine receptor type 5; C-C CKR-5; C-C motif chemokine receptor 5 A159A; CC-CKR-5; CCCKR5; CCR-5; CCR5; CD195; chemokine (C-C motif) receptor 5; chemokine receptor CCR5; CHEMR13; CKR-5; CKR5; CMKBR5; FLJ78003; HIV-1 fusion coreceptor; IDDM22
Gene Symbols: CCR5
Molecular weight: 40,524 Da
Basal Isoelectric point: 9.21  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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