a guanine nucleotide-binding protein of the G12 class of G-alpha proteins. Activates Rho. Protein kinase A blocks Rho activation by phosphorylation of G-alpha(13). Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Regulates cytoplasmic as well as nuclear signaling events such as activation of the Jun N-terminal kinase signaling module, Na+/H+ exchangers, focal adhesion assemblies, and transcriptional activation of specific primary response genes. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(12)
Molecular Function: D5 dopamine receptor binding; G-protein beta/gamma-subunit complex binding; GTP binding; GTPase activity; guanyl-nucleotide exchange factor activity; metal ion binding; protein binding; Rho guanyl-nucleotide exchange factor activity; signal transducer activity; type 1 angiotensin receptor binding
Biological Process: adenylate cyclase-activating G-protein coupled receptor signaling pathway; branching involved in blood vessel morphogenesis; cell differentiation; cell motility; elevation of cytosolic calcium ion concentration; G-protein coupled receptor signaling pathway; in utero embryonic development; phospholipase D activation; platelet activation; positive regulation of apoptosis; regulation of cell migration; regulation of cell shape; regulation of small GTPase mediated signal transduction; Rho protein signal transduction; signal transduction