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TCHP Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells. Belongs to the TCHP family. Note: This description may include information from UniProtKB.
Protein type: Tumor suppressor
Chromosomal Location of Human Ortholog: 12q24.11
Cellular Component: apical cortex; centrosome; cytoplasm; cytosol; desmosome; keratin filament; mitochondrion; plasma membrane
Molecular Function: protein binding
Biological Process: apoptosis; cell projection organization; negative regulation of cell growth
Reference #:  Q9BT92 (UniProtKB)
Alt. Names/Synonyms: MGC10854; mitostatin; Protein TCHP; TCHP; Trichoplein keratin filament-binding protein; trichoplein, keratin filament binding; Tumor suppressor protein
Gene Symbols: TCHP
Molecular weight: 61,072 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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