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PRKD2 a calcium-independent, phospholipid-dependent CAMK kinase of the PKD family. Activated by diacylglycerol and phorbol esters. may play a role in carcinoid tumor progression. Note: This description may include information from UniProtKB.
Protein type: CAMK group; EC; Kinase, protein; Motility/polarity/chemotaxis; PKD family; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 19q13.32
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: protein binding; protein kinase activity; protein serine/threonine kinase activity
Biological Process: activation of CREB transcription factor; activation of NF-kappaB transcription factor; cell death; peptidyl-serine phosphorylation; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of cell adhesion; positive regulation of endothelial cell proliferation; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of interleukin-2 production; positive regulation of interleukin-8 production; positive regulation of peptidyl-serine phosphorylation; positive regulation of T cell receptor signaling pathway; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of vascular endothelial growth factor receptor signaling pathway; protein amino acid autophosphorylation; protein amino acid phosphorylation; sphingolipid biosynthetic process; T cell receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway
Reference #:  Q9BZL6 (UniProtKB)
Alt. Names/Synonyms: HSPC187; KPCD2; nPKC-D2; PKD2; PRKD2; protein kinase D2; Serine/threonine-protein kinase D2
Gene Symbols: PRKD2
Molecular weight: 96,750 Da
Basal Isoelectric point: 6.39  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis  |  Phospholipase Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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