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IVNS1ABP Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines. May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may mediate the inhibition of splicing by NS/influenza virus NS1A protein. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 1q25.3
Cellular Component: cytosol; spliceosome; transcription factor complex
Biological Process: response to virus; RNA splicing; transcription from RNA polymerase III promoter
Reference #:  Q9Y6Y0 (UniProtKB)
Alt. Names/Synonyms: ARA3; aryl hydrocarbon receptor-associated 3; Aryl hydrocarbon receptor-associated protein 3; DKFZp686K06216; FLARA3; FLJ10069; FLJ10411; FLJ10962; FLJ35593; FLJ36593; HSPC068; influenza virus NS1A binding protein; Influenza virus NS1A-binding protein; IVNS1ABP; KIAA0850; KLHL39; NCX downstream gene 1; ND1; NS-1; NS1; NS1-binding protein; NS1-BP; NS1BP
Gene Symbols: IVNS1ABP
Molecular weight: 71,729 Da
Basal Isoelectric point: 5.33  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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