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IRS1 an adaptor protein that is one of the major substrates of the insulin receptor kinase. Contains multiple tyrosine phosphorylation motifs that serve as docking sites for SH2-domain-containing proteins including phosphatidylinositol 3-kinase p85 subunit and GRB-2. Phosphorylated on ser/thr residues by kinases including JNK and IKK. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9q34
Cellular Component: caveola; cytoplasm; cytosol; insulin receptor complex; intracellular; intracellular membrane-bound organelle; nucleus; plasma membrane
Molecular Function: insulin receptor binding; insulin-like growth factor receptor binding; phosphoinositide 3-kinase binding; phosphotyrosine binding; protein binding; protein domain specific binding; protein kinase binding; protein kinase C binding; SH2 domain binding; transmembrane receptor protein tyrosine kinase adaptor protein activity
Biological Process: aging; cellular response to angiotensin; cellular response to brain-derived neurotrophic factor stimulus; cellular response to insulin stimulus; cellular response to radiation; insulin receptor signaling pathway; insulin secretion; insulin-like growth factor receptor signaling pathway; lipid catabolic process; mammary gland development; negative regulation of insulin receptor signaling pathway; negative regulation of insulin secretion; negative regulation of somatostatin secretion; phosphoinositide 3-kinase cascade; positive regulation of cell migration; positive regulation of fatty acid beta-oxidation; positive regulation of glucagon secretion; positive regulation of glucose import; positive regulation of glucose import in response to insulin stimulus; positive regulation of glucose metabolic process; positive regulation of glycogen biosynthetic process; positive regulation of insulin receptor signaling pathway; positive regulation of mesenchymal cell proliferation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphorylation; protein heterooligomerization; protein kinase B signaling; protein localization to nucleus; regulation of gene expression; response to activity; response to caffeine; response to insulin stimulus; response to peptide hormone
Reference #:  P35570 (UniProtKB)
Alt. Names/Synonyms: Insulin receptor substrate 1; IRS-1; Irs1; IRS1IRM; pp185
Gene Symbols: Irs1
Molecular weight: 131,178 Da
Basal Isoelectric point: 8.99  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  Insulin Receptor Signaling  |  mTOR Signaling  |  PI3K/Akt Signaling  |  SAPK/JNK Signaling Cascades  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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