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IRF3 interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 19q13.33
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: identical protein binding; protein binding; protein domain specific binding; protein homodimerization activity; sequence-specific DNA binding; transcription cofactor activity
Biological Process: apoptosis; defense response to virus; negative regulation of interferon type I production; positive regulation of interferon type I production; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; positive regulation of transcription from RNA polymerase II promoter; regulation of interferon type I production; response to DNA damage stimulus; transcription from RNA polymerase II promoter
Disease: Herpes Simplex Encephalitis, Susceptibility To, 7
Reference #:  Q14653 (UniProtKB)
Alt. Names/Synonyms: Interferon regulatory factor 3; IRF-3; IRF3
Gene Symbols: IRF3
Molecular weight: 47,219 Da
Basal Isoelectric point: 5.17  Predict pI for various phosphorylation states
CST Pathways:  Toll-Like Receptor Signaling
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