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Protein Page:

Fer a non-receptor tyrosine kinase of the Fer family. Regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. Increased expression associated with prostate cancer proliferation, and antisense blocks soft agar growth. Note: This description may include information from UniProtKB.
Protein type: EC; Fer family; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group
Chromosomal Location of Human Ortholog: 9q37
Cellular Component: actin cytoskeleton; cell cortex; cell junction; cytoplasm; cytosol; extrinsic component of cytoplasmic side of plasma membrane; lamellipodium; microtubule cytoskeleton; nuclear chromatin; nucleus
Molecular Function: actin binding; ATP binding; cadherin binding; cell adhesion molecule binding; cytoskeletal protein binding; epidermal growth factor receptor binding; gamma-catenin binding; lipid binding; non-membrane spanning protein tyrosine kinase activity; protein kinase activity; protein kinase binding; protein phosphatase 1 binding; Rab GTPase binding; receptor binding
Biological Process: actin cytoskeleton reorganization; cell adhesion; cell differentiation; cell migration; cell proliferation; cellular response to insulin stimulus; chemotaxis; cytokine-mediated signaling pathway; diapedesis; epidermal growth factor receptor signaling pathway; innate immune response; microtubule cytoskeleton organization; mitotic cell cycle; negative regulation of mast cell activation involved in immune response; peptidyl-tyrosine phosphorylation; platelet-derived growth factor receptor signaling pathway; positive regulation of actin filament polymerization; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of NF-kappaB transcription factor activity; protein amino acid phosphorylation; protein autophosphorylation; regulation of cell proliferation; regulation of epidermal growth factor receptor signaling pathway; regulation of mast cell degranulation; regulation of protein amino acid phosphorylation; response to lipopolysaccharide; signal transduction; tyrosine phosphorylation of STAT protein
Reference #:  P09760 (UniProtKB)
Alt. Names/Synonyms: c-FER; Fer; fer (fms/fps related) protein kinase, testis specific 2; Fert2; Flk; Flk_retired; p94-Fer; Proto-oncogene c-Fer; proto-oncogene tyrosine-protein kinase FER; tyrosine protein kinase FLK; Tyrosine-protein kinase Fer; Tyrosine-protein kinase FLK
Gene Symbols: Fer
Molecular weight: 94,314 Da
Basal Isoelectric point: 6.51  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates  |  Wnt/ß-Catenin Signaling
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