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PEX1 Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Belongs to the AAA ATPase family. Interacts directly with PEX6. Interacts indirectly with PEX26, via its interaction with PEX6. Note: This description may include information from UniProtKB.
Protein type: Hydrolase
Chromosomal Location of Human Ortholog: 7q21.2
Cellular Component: cytoplasm; cytosol; peroxisomal membrane; peroxisome
Molecular Function: ATP binding; ATPase activity, coupled; protein binding; protein C-terminus binding; protein complex binding
Biological Process: microtubule-based peroxisome localization; peroxisome organization and biogenesis; protein import into peroxisome matrix; protein targeting to peroxisome
Disease: Heimler Syndrome 1; Peroxisome Biogenesis Disorder 1a (zellweger); Peroxisome Biogenesis Disorder 1b
Reference #:  O43933 (UniProtKB)
Alt. Names/Synonyms: Peroxin-1; peroxisomal biogenesis factor 1; Peroxisome biogenesis disorder protein 1; Peroxisome biogenesis factor 1; PEX1; Zellweger syndrome; ZWS; ZWS1
Gene Symbols: PEX1
Molecular weight: 142,867 Da
Basal Isoelectric point: 5.91  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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