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JIP3 a member of the JNK-interacting protein group of scaffold proteins that selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies in the mouse suggested that this protein may interact with and regulate the activity of numerous protein kinases of the JNK signaling pathway. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: cytoplasm; Golgi membrane
Molecular Function: JUN kinase binding; kinesin binding; MAP-kinase scaffold activity; protein binding; receptor signaling complex scaffold activity
Biological Process: activation of JNK activity; regulation of JNK cascade; vesicle-mediated transport
Reference #:  Q9UPT6 (UniProtKB)
Alt. Names/Synonyms: C-jun-amino-terminal kinase interacting protein 3; C-Jun-amino-terminal kinase-interacting protein 3; DKFZp762N1113; FLJ00027; homolog of Drosophila Sunday driver 2; JIP-3; JIP3; JNK MAP kinase scaffold protein 3; JNK-interacting protein 3; JNK/SAPK-associated protein-1; JNK/stress-activated protein kinase-associated protein 1; JSAP1; KIAA1066; MAPK8IP3; mitogen-activated protein kinase 8 interacting protein 3; Mitogen-activated protein kinase 8-interacting protein 3; syd; SYD2
Gene Symbols: MAPK8IP3
Molecular weight: 147,457 Da
Basal Isoelectric point: 5.26  Predict pI for various phosphorylation states
CST Pathways:  SAPK/JNK Signaling Cascades
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Protein Structure Not Found.
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