Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

JIP3 a member of the JNK-interacting protein group of scaffold proteins that selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies in the mouse suggested that this protein may interact with and regulate the activity of numerous protein kinases of the JNK signaling pathway. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17 A3.3|17 12.53 cM
Cellular Component: axolemma; cytoplasm; dendrite; Golgi membrane; neuron projection; plasma membrane; smooth endoplasmic reticulum
Molecular Function: JUN kinase binding; kinesin binding; MAP-kinase scaffold activity; mitogen-activated protein kinase kinase binding; mitogen-activated protein kinase kinase kinase binding; protein binding; receptor signaling complex scaffold activity
Biological Process: activation of JNK activity; alveolus development; axon guidance; forebrain development; in utero embryonic development; JNK cascade; positive regulation of JNK activity; positive regulation of neuron differentiation; post-embryonic development; protein localization; regulation of gene expression; regulation of JNK cascade; respiratory gaseous exchange; vesicle-mediated transport
Reference #:  Q9ESN9 (UniProtKB)
Alt. Names/Synonyms: BB120594; c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1; C-Jun-amino-terminal kinase-interacting protein 3; D17Wsu15e; JIP-3; Jip3; JNK MAP kinase scaffold protein 3; JNK-interacting protein 3; JNK/SAPK-associated protein 1; JNK/SAPK-associated protein 1c; JSAP1; JSAP1a; JSAP1b; JSAP1c; JSAP1d; JUN/SAPK-associated protein 1; Mapk8ip3; mitogen activated protein kinase 8 interacting protein 3; mitogen-activated protein kinase 8 interacting protein 3; Mitogen-activated protein kinase 8-interacting protein 3; mKIAA1066; Sunday driver 2; Syd2
Gene Symbols: Mapk8ip3
Molecular weight: 147,561 Da
Basal Isoelectric point: 5.3  Predict pI for various phosphorylation states
CST Pathways:  SAPK/JNK Signaling Cascades
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene