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CCNA2 a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 4q27
Cellular Component: cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytosol; female pronucleus; male pronucleus; nucleoplasm; nucleus
Molecular Function: protein binding; protein domain specific binding; protein kinase binding
Biological Process: cell division; cellular response to cocaine; cellular response to estradiol stimulus; cellular response to hypoxia; cellular response to insulin-like growth factor stimulus; cellular response to leptin stimulus; cellular response to luteinizing hormone stimulus; cellular response to nitric oxide; cochlea development; G2/M transition of mitotic cell cycle; histone phosphorylation; organ regeneration; positive regulation of fibroblast proliferation; positive regulation of transcription, DNA-templated; protein deubiquitination; Ras protein signal transduction; regulation of cell cycle; response to glucagon; viral process
Reference #:  P20248 (UniProtKB)
Alt. Names/Synonyms: CCN1; CCNA; CCNA2; cyclin A2; Cyclin-A; Cyclin-A2
Gene Symbols: CCNA2
Molecular weight: 48,551 Da
Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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