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ATP13A2 May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Expressed in brain; protein levels are markedly increased in brain from subjects with Parkinson disease and subjects with dementia with Lewy bodies. Detected in pyramidal neurons located throughout the cingulate cortex. In the substantia nigra, it is found in neuromelanin- positive dopaminergic neurons. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.3.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of Human Ortholog: 1p36.13
Cellular Component: autophagic vacuole; cell soma; integral to plasma membrane; late endosome; lysosomal lumen; lysosomal membrane; lysosome; multivesicular body; neuron projection; transport vesicle; vesicle
Molecular Function: calcium-transporting ATPase activity; cation-transporting ATPase activity; manganese ion binding; protein binding; zinc ion binding
Biological Process: cellular calcium ion homeostasis; cellular cation homeostasis; cellular iron ion homeostasis; cellular zinc ion homeostasis; positive regulation of protein secretion; protein amino acid autophosphorylation; regulation of autophagic vacuole size; regulation of endopeptidase activity; regulation of macroautophagy; zinc ion homeostasis
Disease: Kufor-rakeb Syndrome; Spastic Paraplegia 78, Autosomal Recessive
Reference #:  Q9NQ11 (UniProtKB)
Alt. Names/Synonyms: AT132; ATP13A2; ATPase type 13A2; FLJ26510; HSA9947; KRPPD; PARK9; Probable cation-transporting ATPase 13A2; putative ATPase
Gene Symbols: ATP13A2
Molecular weight: 128,794 Da
Basal Isoelectric point: 8.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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