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FIS1 Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. Belongs to the FIS1 family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Mitochondrial
Chromosomal Location of Human Ortholog: 7q22.1
Cellular Component: integral to mitochondrial outer membrane; integral to peroxisomal membrane; membrane; mitochondrion; peroxisome; protein complex
Molecular Function: protein binding; receptor binding
Biological Process: elevation of cytosolic calcium ion concentration; elevation of mitochondrial calcium ion concentration; mitochondrial fission; mitochondrial fragmentation during apoptosis; mitochondrial fusion; mitochondrion degradation; peroxisome fission; positive regulation of caspase activity; protein homooligomerization; protein targeting to mitochondrion; reduction of endoplasmic reticulum calcium ion concentration; release of cytochrome c from mitochondria
Reference #:  Q9Y3D6 (UniProtKB)
Alt. Names/Synonyms: CGI-135; FIS1; FIS1 homolog; fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae); H_NH0132A01.6; hFis1; Mitochondrial fission 1 protein; tetratricopeptide repeat domain 11; Tetratricopeptide repeat protein 11; TPR repeat protein 11; TTC11
Gene Symbols: FIS1
Molecular weight: 16,938 Da
Basal Isoelectric point: 8.84  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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